Wish you a very happy Thanksgiving day : )
Thursday, November 22, 2018
Thursday, August 23, 2018
No Evidence of Disease Activity after Five Years of Autologous Hematopoietic Stem Cell Therapy for Multiple Sclerosis: Detailed Report of Five Patients
Background:: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. Its treatment has focused on inflammation control as early as possible to avoid disability. Autologous hematopoietic stem cell transplantation (AHSCT) has been used for treating MS since 1996 without decisive results regarding benefits or long-term efficacy. We report the follow-up of five patients who were evaluated for up to five years after the stem cell transplantation treatment and who did not present any disease activity.
Methods: Five patients followed up at an MS center in Belo Horizonte, Brazil, who had relapsing-remitting MS with high disease activity, underwent AHSCT from 2009 to 2011. They were evaluated clinically, with magnetic resonance imaging, and by the Expanded Disability Status Scale, every six months and up to five years after transplantation.
Results: The patients in our study comprised four women and one man, with age ranging from 25 to 50 years, and time since disease onset ranging from 4 to 17 years at the time of the procedure. Four patients improved, one patient was stabilized, and all patients continued to be free of disease activity after 5 years.
Discussion:: Through improving patient selection and decreasing the time since disease onset, AHSCT could stop epitope spreading and disease progression. Despite multiple other therapeutic choices, AHSCT is a treatment to consider for aggressive MS disease.
Keywords: Stem cell; Autologous Transplant; Multiple Sclerosis Treatment; NEDA
Friday, September 2, 2016
Journal of Nutrition and Obesity
Dr. Katsunori Nonogaki is a specialist of Diabetes care and
Internal medicine. He received PhD in Endocrinology, Metabolism, and Diabetes
from Nagoya University Graduate School of Medicine, Japan. His research has mainly focused on “the role of the central
nervous system in the regulation of hepatic glucose production”.
Journal of Gastroenterology and Metabolism
Dr. Pia Munkholm currently working as a professor in the Department of Gastroenterology at the University Of Copenhagen, Denmark. She is a member of many gastroenterology associations i.e., American Gastroenterology Association as Fellow, Member of EC-IBD, European Collaborative study group of Inflammatory Bowel Disease. She has received several honors. She is serving as a referee for different international gastroenterology journals. She has many scientific publications and abstracts presented at international scientific meetings.
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Journal of Pediatric Disorders and Neonatal Care
Dr. Mirko Bertozzi is currently working as an Associate professor in the Department of Pediatric Surgery at S. Maria Della Misericordia Hospital in the University of Perugia, Italy. He received his Ph.D in Pediatric Surgery from the University of Bologna, Italy. He is an Executive board member for the Italian Society of Pediatric Video surgery –SIVI and he also serves as an associate member for Italian, European pediatric societies and Italian Group of Endoscopic Mini invasive Pediatric surgery.
Friday, June 3, 2016
A Case Report of Psychosis in a Patient of Myxedema: Myxedema Madness
Hypothyroidism is one of the most important causes of
organic psychosis and sometimes can be missed. There are some cases showing
extreme degree of hypothyroidism leading to psychiatric illnesses like mania,
depression and psychosis. In present case, a 21year old well-functioning female
developed hypothyroidism initially with symptoms of Myxedema which was
undiagnosed for 2 years. She had psychotic features after 2 years in form of
hallucinatory behavior, poor self-care, persecutory and referential delusions, episodes
of violent behavior and suicidal attempts. Thyroid supplementation was given in
therapeutic dose but there was no improvement in her clinical profile. It was
decided by experts to add antidepressant and antipsychotic medicines. Patient
had marked improvement. She started talking with family, her aggression
subsided. Only persecutory delusion and memory impairment persisted so doses of
antipsychotic medicine was gradually built up.
Click here to View Case Report Journal of Scholarena
Administration of Vasoconstrictor, But Not Volume Expander Prevents Maternal Hypotension During Spinal-Epidural Anesthesia For Elective Cesarean Section
Administration of vasoconstrictor preventing maternal
hypotension after combined spinal-epidural , anesthesia(CSEA) in elective
cesarean section patients.A total of 240 full-term, single pregnancy women,
undergoing elective cesarean section in CSEA were included. Multiple linear
regression analysis was used to identify major contributing factors for
maternal hypotension from 18 independent variables. The model was set as
αentry= 0.05, αremove = 0.15, and condition index <15. The incidence of
hypotension from different combinations of vasoconstrictors for hypotension
prevention were calculated and compared, then correlated with pH and base excess
in neonatal umbilical venous blood, as well as 1 and 5 min Apgar score, using
one-way ANOVA. p<0.05 was considered to be significant difference. Continuous
dosage of phenylephrine decrease incidence of maternal hypotension after CSEA
for elected cesarean section.
Friday, October 31, 2014
Chronotherapeutic Drug Delivery of Pectin Vs. Guar Gum, Xanthan Gum Controlled Release Colon Targeted Directly Compressed Propranolol Hcl Matrix Tablets
The study has been designed to develop a delayed release matrix tablets by
using various natural polymers. The polsaccharide Pectin was used in the
formulation Vs. Xanthan gum and Guar gum. The performance of Pectin
Vs. other conventional polysaccharides was demonstrated in this work. A
model drug Propranolol HCl was incorporated in the formulation design in
order to access the drug release profile.
Saturday, October 25, 2014
Mustafa Yavuz - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Mustafa Yavuz is a Professor at the University of Waterloo and the director of the Nano/Micro-Systems Research Laboratory at the University Waterloo, which has been supported by the Canada Foundation for Innovation (CFI) since 2005. He received his PhD degrees in materials engineering and applied physics from the University of Wollongong, Australia. He worked at the Institute for Materials Research (IMR), Tohoku University in Japan; Accelerator Technology Corp, Bryan, Texas; and the Texas A&M University, where he was one of the founding members of the Interdisciplinary Graduate Materials Science and Engineering Program.
Renjun Pei - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Renjun Pei is working as Professor in Division of Nanobiomedicine at Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences. Prior to this current position he worked as Associate research scientist in the Department of Medicine, Columbia University and as JSPS postdoctoral research scientist in Institute for Chemical Research at Kyoto University, Japan. He obtained his Ph.D. in Chemistry in 1998 from Wuhan University.
Weihai Ni - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Weihai Ni is working as a Professor in the Division of i-Lab at Suzhou Institute of Nano-Tech and Nano-Bionics, China. He obtained his B.S. and M.S. degrees in physics from Shanghai Jiao Tong University China and Ph.D. degree in physics from the Chinese University of Hong Kong. He was a postdoctoral research associate at University of Vigo, Spain and was also an Alexander von Humboldt fellow in the photonics and optoelectronics group of Ludwig-Maximilians-Universität München, Germany.
Wang Lei - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Wang Lei has obtained his PhD from Department of Polymer/Nano Science & Technology, Chonbuk National University, he is a Post Doc fellow at Polymer BIN Fusion Research Center Chonbuk National University. He worked as a Lecture for Materials Science and Engineering at University of Science and Technology, Beijing. He is presently working as an Associate Professor, CAS key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology. He has number of publications to his name.
Adnane Abdelghani - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
Dr. Adnane Abdelghani is a Professor in the National Institute of Applied Science and Technology (INSAT), Tunisia. He is working mainly in the field of Microsensors and Microsystems. He obtained the master degrees in "Microelectronics Devices" at the INSA of Lyon (France) in 1994, than a Ph.D. thesis from Ecole Centrale of Lyon (France) in 1997. He obtained a post-doc position in Germany between 1997-2000 in the field of biophysics
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Dr. Adnane Abdelghani is a Professor in the National Institute of Applied Science and Technology (INSAT), Tunisia. He is working mainly in the field of Microsensors and Microsystems. He obtained the master degrees in "Microelectronics Devices" at the INSA of Lyon (France) in 1994, than a Ph.D. thesis from Ecole Centrale of Lyon (France) in 1997. He obtained a post-doc position in Germany between 1997-2000 in the field of biophysics
Mohamed Khayet - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Mohamed Khayet is a professor of Thermodynamics, Statistical Physics, General Physics and Renewable Energy Applications at the Department of Applied Physics I, Faculty of Physics, University Complutense of Madrid and Associated Researcher in the Institute IMDEA Water, IMDEA Madrid Institute for Advanced Studies.
Hongjing Dou - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Hongjing Dou is working as Associate Professor in the School of Materials Science and Engineering at Shanghai Jiao Tong University China. She completed Ph.D in the Department of Macromolecular Science at Fudan University. She also served as postdoctoral research associate.at Queen’s University in Canada.
Xiaobin HU - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
Dr. Xiaobin HU is presently working as Associated Professor in the School of Materials Science and Engineering at Shanghai Jiaotong University. He received his Master degree in Mechanic Engineering from the East China University of Science and Technology in 1995 and PhD in Materials Science from the Shanghai Jiaotong University in 2004. He then was a postdoctoral fellow in Chemistry at Tsinghua University. He had more than ten year’s professional experience in international companies as an Engineer and Manager before he joined Shanghai Jiaotong University.
Nguyen TK Thanh - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Dr. Nguyen TK Thanh is a Professor of Nanomaterials. She is based at UCL Healthcare Biomagnetic and Nanomaterials Laboratories, at The Royal Institution of Great Britain, the oldest independent scientific research body in the world and Department of Physics and Astronomy, University College London, UK.She is also a visiting Professor at European Engineering School in Chemistry, Polymers and Materials, University of Strasbourg, France and Japan Advanced Institute of Science and Technology, Japan.
Abebaw Jemere - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Dr. Abebaw Jemere is a Research Officer in National Institute for Nanotechnology at University of Alberta, Canada. In 2002 he received Ph.D in Analytical Chemistry at University of Alberta and worked as Scientist in CMC Microsystems, Ontario and in Advanced Integrated MicroSystems Company at Alberta.
Guang Lu - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Scholarena Journal of Nanoscience and Nanotechnology (SAJNN)
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Dr. Guang Lu is a Professor in the Institute of Functional Nano & Soft Materials at Soochow University, China. Prior to the current position he worked as Postdoctoral Research Fellow in the School of Materials Science and Engineering at Nanyang Technological University. He received Ph.D. in Polymer Chemistry and Physics at College of Chemistry, Jilin University.
Martin Michaelis - Editorial Board Member of SAJ Nanoscience and Nanotechnology
Dr. Martin Michaelis is presently working as Professor and Chairperson of Cell Biology, Centre for Molecular Processing and School of Biosciences at University of Kent, UK. He completed his PhD in pharmaceutics in Frankfurt am Main, Germany, working on drug carrier systems including nanoparticles and liposomes.
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