The Antioxidant Flavonoids, Orientin and Vicenin Enhance Repair of Radiation-Induced Damage

Orientin (Ot) and vicenin (Vc), two water soluble flavonoids isolated from the Indian Holy Basil, are potent radioprotectants, but the mechanisms of protection are not fully understood. In the present study, we investigated the effects of these flavonoids as antioxidants in chemical systems and plasmid DNA and radioprotectants in bacterial and mammalian cells. The radical scavenging activities of Ot and Vc were assessed in two chemical systems, dipehnylpicrylhydrazyl (DPPH) and 2,2´-azino-bis(3-thylbenz-thiazoline-6-sulfonic acid) (ABTS) by estimating absorbance at 517 and 734 nm, respectively.

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