This editorial describes evolving chronophysiomical mediations of appetite and food intake (AFI). Chronophysiomics is a multiscience involving integrated chronophysiology and functional omics biotechnologies. Chronophysiology as an evolutionary interscience has enabled humans and animals to better cope with the changing environment from the mother nature towards modernity. This trend continues to evolve into postmodernity. With the recent discoveries on timing of eating and feeding orchestrating circadian and postprandial nutrient intake and metabolic rhythms in animal models [1-7], time has already come to contemplate chronophysiology as a key regulator of AFI. Omics biotechnologies (e.g., genomics, proteomics, lipidomics, transcriptomics, and metabolomics) provide new tools to further our perceptions of possible mechanisms underlying such regulations. This is important since AFI affects directly or circuitously risks of health issues such as obesity, diabetes mellitus, blood pressure and cardiovascular diseases.