Friday, September 12, 2014

Preparation and Characterization of Biodegradable Glimepiride Loaded PLA Nanoparticles by o/w Solvent Evaporation Method Using High Pressure Homogenizer: A Factorial Design Approach

Glimepiride is used for the treatment of type 2 diabetes mellitus, one of the third generation sulfonylurea drugs having poor aqueous solubility, slow dissolution rate and low elimination half life. The Aim of the present study was to prepare Glimepiride loaded poly-D, L-lactide (PLA) Nanoparticles by o/w solvent evaporation method using high speed homogenizer. Prepared Nanoparticles were characterized for the drug content, encapsulation efficiency.

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