Cervical metastasis is often the only presenting feature in patients with squamous cell carcinoma of the head and neck (HNSCC). These metastases frequently undergo cystic degeneration, and may be difficult to distinguish from other benign cystic squamous lesions of the head and neck. Fine needle aspiration for cytopathology (FNAC) is frequently performed, but the results obtained may not be conclusive. P16 immunohistochemistry may be carried out. However, the value of this test in differentiating between benign and malignant cystic lesions of the head and neck remains unclear.
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